Molecular mechanism of chromium (VI) Induced Cytotoxicity and Apoptosis in L929 Mouse Fibroblasts
نویسندگان
چکیده
منابع مشابه
[Molecular mechanism involved in chromium(VI) toxicity].
Chromium exists in many different oxidation states in the environment, Cr(VI) and Cr(III) being the most stable forms. Chromium has been known for over 100 years to be a human carcinogen. The greatest risk of cancer from chromium exposure is associated with Cr(VI). Cr(VI) enters cells via the sulfate anion transporter system and is reduced to intermediate oxidation states, such as Cr(V) and Cr(...
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The cellular responses to carcinogen exposure influence cellular fate, which in turn modulates the neoplastic response. Certain hexavalent chromium [Cr(VI)] compounds are implicated as occupational respiratory carcinogens at doses that are both genotoxic and cytotoxic. We examined the mechanism of Cr(VI)-induced apoptosis in normal human fibroblasts (BJ) immortalized by human telomerase gene tr...
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ژورنال
عنوان ژورنال: Egyptian Academic Journal of Biological Sciences. A, Entomology
سال: 2009
ISSN: 2090-0813
DOI: 10.21608/eajbsa.2009.15518